11 Best TV Shows About Sisters That Nail the Love/Hate Bond

There’s something wildly comforting (and occasionally unhinged) about a great “sisters” show. Sisters are the people who can read you in one glance, defend you like it’s their job, and still bring up that one embarrassing thing you did in 2009 at the worst possible moment.

The best series about sisterhood don’t just give us matching outfits and heartfelt hugs. They show us the messy and contradicting parts of having a sister. The constant rivalry that somehow also comes with deep-rooted loyalty, constant bickering that goes hand in hand with inside jokes for days and the weird telepathy that only comes from growing up together (or surviving something together). These are the shows that showcase all the intricacies of a sisterhood in all sorts of scenarios, from mundane and painfully realistic to magical and otherworldly.

Charmed—Sisterhood as a Literal Superpower

If you want the gold standard of “sisters first, everything else second,” Charmed is it. The series centers on the Halliwell sisters—Prue, Piper, and Phoebe—whose bond activates their magic (“the Power of Three”), and later expands when Paige joins the family.
What makes Charmed work isn’t just the demon-fighting. It’s the way the show treats sisterhood like the engine of the story. The sisters engage in arguments about responsibilities, clash over life decisions, experience jealousy and fear, yet consistently support each other during crucial moments. Even when their lives are chaotic—jobs, relationships, grief, identity—the one constant is that they keep coming back to the idea of “we’re a unit.”
In a genre that can easily lean into melodrama, Charmed earns its emotional beats because the sister dynamic feels like the real plot twist: magic is the background noise; family is the main event.

Sabrina the Teenage Witch—The aunts who feel like sisters

Technically, Sabrina the Teenage Witch is about a teenage girl discovering she’s actually a witch. But her homelife is run by two sisters who are raising her—Zelda and Hilda Spellman. Their relationship has that classic sibling energy. They bicker all the time, they tease each other mercilessly bickering, but they also love each other deeply and can work as a surprisingly good team when things get serious.
Zelda and Hilda represent two archetypes of adults—one more practical, one more chaotic—and it’s their push-pull dynamic that makes the household feel lived-in. The plotlines in this show can and often do get very silly, but the emotional takeaway is very real. Families come in all sorts of shapes and sizes, but they thrive on a good routine, patience, and people who stick around while you figure it out. If you like “sisters raising a kid together” energy, this one’s a cozy classic.

The Powerpuff Girls—Sisters, but make it tiny and feral

If you grew up with The Powerpuff Girls, you already know the deal: Blossom is the planner, Bubbles is the heart, Buttercup is the chaos gremlin. They’re “created” rather than born, but the show writes them like siblings in the purest sense—different personalities, shared upbringing, shared mission, and a lot of screaming before bedtime.
What makes it such a smart sisters show is how often the conflicts are emotional, not just superhero-based. They constantly learn how to collaborate as a team without sacrificing their individuality. And honestly? That’s basically the lifelong sister challenge in one sentence.

Modern Family—The sibling dynamic that sneaks up on you

Modern Family is an ensemble about interconnected relatives, but one of its most consistent “sisters” threads is in the Dunphy household—especially the Haley/Alex relationship. The show lets them evolve from classic teen sister stereotypes (popular vs. nerdy) into something more nuanced: two sisters who annoy each other, misunderstand each other, and still quietly root for each other when no one’s watching.
The best part is that Modern Family doesn’t force big speeches every time. It gives you small moments—support during breakups, pride during milestones, the occasional “only I’m allowed to make fun of her” protective instinct—that feel extremely true to life.